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KMID : 0616120070380020117
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Korean Journal of Pharmacognosy
2007 Volume.38 No. 2 p.117 ~ p.122
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(Induction of Enhancement of Anti-Tumor Immunity by Polysaccharides Fractionated from Acanthopanx Senticosus)
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Yoon Taek-Joon
Sung Ji-Yeon
Yu Kwang-Won
Lee Ho
Lee Kwang-Ho
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Abstract
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The specific activation of the immune system to control cancer growth in vivo has been a long-standing goal in cancer immunology. Whole tumor Iysates have been used either alone or combined with adjuvants to induce specific immune response in vivo. Here, we examined whether freezing/thawing (F/T) colon26-M3.1 tumor cell admixed with EN-3, glycoprotein purified from Acanthopanx Senticosus, could stimulate in vivo immunity by using a murine experimental tumor metastasis model produced by colon26-M3.1 carcinoma cells. Vaccination of mice with F/T treated colon26-M3.1 carcinoma cells in combination with EN-3 as an adjuvant resulted in a significant inhibition in tumor metastasis of mice against live colon26-M3.1 carcinoma challenge. In addition, the splenocytes from vaccinated mice exhibited a higher proliferating activity and secreted interferon-{gamma}. These results suggest that EN-3 can be applied to immunoadjuvant to enhance the antitumor immunity in vivo.
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KEYWORD
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Acanthopanax senticosus, tumor immunity, splenocytes, cytokines
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